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Kinetics of ligand binding to CYP3A4. Kinetic traces were recorded at ambient tem peratures after mixing 2 μM CYP3A4 with 20 μM solutions of the investigated compounds or ritonavir (RIT); fitting curves are shown as solid colored lines. All reactions were biphasic within the studied time interval. The rate constants for the fast phase (kfast) are listed in Table 1.
