Table 2.
HCV Direct Acting Antivirals as Substrates and/or Inhibitors with Select Human Hepatocyte Drug Transporters
| Drug Transporters | HCV Direct Acting Antivirals (References) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BOC (38–41) | DCV (42,43) | DSV (44–46) | EBR (47) | GZR (47–49) | LDV (44) | OBV (44,45) | PTV (44,45) | SMV (42) | SOF (50) | TVR (20–22) | ||
| Basolateral Influx Transporters (sinusoidal blood → intrahepatic) | OATP1B1 | I | I | - | - | S | - | - | S, I | S, I | - | I |
| OAT1PB3 | - | I | - | - | S | - | - | S, I | S, I | - | ||
| OATP2B1 | - | - | - | - | - | - | - | I | S | - | I | |
| Canalicular Efflux Transporters (intrahepatic → bile canaliculus) | MRP2 | - | - | - | - | - | - | - | - | S, I | - | - |
| BCRP | - | I | S, I | I | I | S, I | S | S, I | S | S | - | |
| P-gp | S, I | S, I | S, I | S | S | S, I | S | S | S, I | S | S, I | |
| BSEP | - | - | - | - | - | - | - | - | I | - | - | |
BOC = boceprevir; BRCP = Breast Cancer Resistance Protein; BSEP = Bile Salt Export Pump; DCV = daclatasvir; DSV = dasabuvir; EBR = elbasvir; GZR = grazoprevir; inhibitors = I; LDV = ledipasvir; MRP = Multidrug Resistance-associated Protein; OATP = Organic Anion Transporting Polypeptide; OBV = ombitasvir; P-gp = P-glycoprotein; PTV = paritaprevir; substrate = S; SMV = simeprevir; SOF = sofosbuvir; TVR = telaprevir