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. 2018 Feb 1;32(3-4):224–229. doi: 10.1101/gad.306464.117

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© 2018 Sansam et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 5. — The BET inhibitor affects S-phase progression. (A) BRD4 and TICRR immunoblots after MZ1 or cis-MZ1 treatment of U2OS cells for the indicated times. (B–D) Synchronized U2OS cells were released into S phase with 1 µM MZ1 or cis-MZ1 and harvested at the indicated times for FACS DNA content analysis (B), spatiotemporal replication pattern scoring (C), or S-phase exit (D). DNA replication foci were detected using PCNA immunofluorescence in C and D.