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. 2017 Apr 27;17(1):1–7. doi: 10.1093/bfgp/elx008

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© The Author 2017. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — A breakdown of potential situations encountered when conducting genetic analysis on collected samples and practical examples of cases clearly belonging to each quarter. Support for returning information to the donor is strong when a finding is both reliable (possessing a high level of clinical validity) and actionable (the donor can act on the given information) as in the example given in Square 2 and, there is little support for providing information that is neither reliable nor actionable (Square 3). Decisions are harder and in greater need of consideration when the reliability of findings is low (Square 4) or when there is little the donor can do about the situation (Square 1).