Figure 1.

Regulatory states in developmental gene regulation. Scheme showing the expression of a cell fate-specific regulatory state (center) as controlled by the circuitry of a developmental GRN (top). The regulatory state consists of transcription factors co-expressed in a given nucleus, some of which are regulated by developmental signaling interactions (black). While the expression of all genes depends on the regulatory state, the specific combination of transcription factors regulating individual genes may vary (bottom). (A colour version of this figure is available online at: https://academic.oup.com/bfg)