Table 3.

Incidence Rate Ratios for Incident End-Stage Renal Disease According to Categories of 1,5-Anhydroglucitol Level, Atherosclerosis Risk in Communities Study, United States, 1990–2013

Model	1,5-Anhydroglucitol Level, μg/mL						P for Trend
	≥10.0 (n = 11,671)		6.0–9.9 (n = 690)		<6.0 (n = 916)
	IRR	95% CI	IRR	95% CI	IRR	95% CI
1a	1	Referent	3.54	2.42, 5.18	10.53	8.24, 13.45	<0.001
2b	1	Referent	3.09	2.11, 4.53	8.18	6.37, 10.52	<0.001
3c	1	Referent	2.47	1.68, 3.64	6.52	5.00, 8.51	<0.001
4d	1	Referent	2.37	1.60, 3.51	5.93	4.53, 7.77	<0.001
5ae	1	Referent	2.07	1.38, 3.10	3.36	2.31, 4.90	<0.001
5bf	1	Referent	1.86	1.24, 2.80	2.04	1.32, 3.15	<0.001

Abbreviations: CI, confidence interval; IRR, incidence rate ratio.

^a Model 1: no covariates (unadjusted).

^b Model 2 adjusted for demographics (age, sex, race).

^c Model 3: model 2 with the addition of estimated glomerular filtration rate based on creatinine and cystatin C (modeled as linear spline terms with knots at 60 mL/min/1.73 m² and 90 mL/min/1.73 m²).

^d Model 4: model 3 with the addition of hypertension, body mass index, current smoking.

^e Model 5a: model 4 with the addition of fasting glucose.

^f Model 5b: model 4 with the addition of glycated hemoglobin.