Table 6.
Heart rate and heart rate-modulating medications in Europeana patients with stable CAD and Europeana patients with stable CAD and angina during observationb
| Parameter | Baseline | 1st year | 2nd year | 3rd year | 4th year | 5th year |
|---|---|---|---|---|---|---|
| Patients with stable CAD (N, [%]) | ||||||
| 17,902 | 17,038 | 16,089 | 14,851 | 13,289 | 11,954 | |
| HR, mean (SD) palpation (bpm) | 67.3 (10.5) | 66.3 (9.8) | 65.9 (9.7) | 66.0 (9.6) | 66.1 (9.5) | 66.0 (9.1) |
| HR, mean (SD) ECG (bpm) | 66.5 (11.2) | 65.7 (10.4) | 65.3 (10.3) | 65.4 (10.2) | 65.6 (10.2) | 65.5 (9.8) |
| Medications (N, %) | ||||||
| Beta-blocker | 14,077 (78.7) | 12,900 (76.5) | 11,917 (75.9) | 10,910 (75.9) | 9647 (76.5) | 8568 (76.7) |
| Ivabradine | 2852 (15.9) | 3182 (18.9) | 3289 (20.9) | 3210 (22.3) | 2965 (23.5) | 2695 (24.1) |
| Verapamil or dilitiazem | 914 (5.1) | 807 (4.8) | 728 (4.6) | 603 (4.2) | 472 (3.7) | 407 (3.6) |
| Digoxin and derivates | 381 (2.1) | 374 (2.2) | 347 (2.2) | 338 (2.3) | 292 (2.3) | 262 (2.3) |
| Patients with stable CAD and angina | ||||||
| (N, [%]) | 4873 (27.2) | 3599 (21.3) | 3271 (20.6) | 2929 (19.9) | 2613 (19.9) | 2384 (20.3) |
| HR, mean (SD) palpation (bpm) | 69.7 (10.8) | 68.2 (9.5) | 67.4 (9.3) | 67.3 (8.9) | 66.9 (8.8) | 66.9 (8.3) |
| HR, mean (SD) ECG (bpm) | 68.8 (11.6) | 67.3 (10.2) | 66.5 (9.9) | 66.2 (9.6) | 66.1 (9.6) | 66.1 (8.9) |
| HR ≥ 70 bpm palpation (N, %) | 2351 (48.2) | 1495 (41.5) | 1218 (37.2) | 1086 (37.1) | 866 (33.1) | 755 (31.7) |
| HR ≤ 60 bpm palpation (N, %) | 1102 (22.6) | 860 (23.9) | 827 (25.3) | 745 (25.4) | 696 (26.6) | 570 (23.9) |
| Medications (N, %) | ||||||
| Beta-blocker | 3960 (81.3) | 2944 (81.8) | 2652 (81.5) | 2381 (82.0) | 2123 (82.4) | 1917 (81.9) |
| Ivabradine | 1417 (29.1) | 1142 (31.7) | 1156 (35.5) | 1110 (38.2) | 1030 (40.0) | 925 (39.5) |
| Verapamil or dilitiazem | 251 (5.2) | 156 (4.3) | 135 (4.1) | 107 (3.7) | 76 (3.0) | 81 (3.5) |
| Digoxin and derivates | 102 (2.1) | 89 (2.5) | 89 (2.7) | 78 (2.7) | 63 (2.4) | 55 (2.4) |
bpm beats per minute, HR heart rate, N number of patients, SD standard deviation
aEurope = Belgium, Bulgaria, Czech Republic, Denmark, France, Germany, Greece, Hungary, Ireland, Italy, Latvia, Lithuania, Luxembourg Netherlands, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Switzerland, United Kingdom, Ukraine
bmean values as well as percentages are of the data available