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GLP-1 secretion upon glucose stimulation in human gut mucosae. A: Concentration–response curve for GLP-1 secretion in response to increasing glucose levels in human ileum tissue (n = 5). A glucose concentration of 300 mmol/L potently triggered GLP-1 secretion from L cells in human ileal (n = 19) (B), duodenal (n = 6) (C), and colonic (D) mucosae (n = 24). Bar graph data are the mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 compared with respective control groups.
