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. 2017 Feb 28;66(6):1713–1722. doi: 10.2337/db16-0874

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© 2017 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.

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The primary analyses conducted in ALSPAC/ARIES. In stage 1, 118 associations between published type 2 diabetes SNPs and genome-wide methylation were identified. In stage 2, a further 226 mQTLs were identified between 202 additional independent non–type 2 diabetes SNPs and the CpGs identified in stage 1. DIAGRAM data were then used to assess the relationship of these independent mQTLs with type 2 diabetes disease risk in order to strengthen causal inference that DNA methylation is acting as a mediating mechanism. T2D, type 2 diabetes.