Table 2.
The number of breast cancer patients exposed to each of 30 COSMIC mutational signatures (columns) at different minimal contribution levels (rows) with P-value of 0.01 as assessed by bootstrap analysis of the perturbed patient’s mutational catalogs
| Exposure | Signatures |
|||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| threshold | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 |
| >0.01 | 523 | 335 | 250 | 7 | 91 | 8 | 10 | 434 | 246 | 13 | 18 | 15 | 386 | 5 | 12 | 117 | 9 | 66 | 3 | 5 | 6 | 0 | 0 | 0 | 8 | 7 | 0 | 4 | 2 | 8 |
| >0.05 | 423 | 165 | 210 | 1 | 62 | 6 | 0 | 312 | 65 | 0 | 0 | 9 | 210 | 2 | 1 | 32 | 4 | 25 | 0 | 3 | 3 | 0 | 0 | 0 | 0 | 5 | 0 | 1 | 0 | 1 |
| >0.10 | 347 | 104 | 175 | 0 | 33 | 6 | 0 | 174 | 12 | 0 | 0 | 8 | 117 | 0 | 0 | 8 | 3 | 9 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 4 | 0 | 0 | 0 | 1 |
| >0.15 | 265 | 69 | 154 | 0 | 12 | 4 | 0 | 91 | 2 | 0 | 0 | 7 | 78 | 0 | 0 | 2 | 3 | 5 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 1 |
| >0.20 | 177 | 49 | 136 | 0 | 4 | 2 | 0 | 36 | 0 | 0 | 0 | 4 | 61 | 0 | 0 | 1 | 2 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 1 |
| >0.25 | 96 | 35 | 120 | 0 | 1 | 2 | 0 | 16 | 0 | 0 | 0 | 3 | 45 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 1 |
Note: The 12 known breast cancer signatures are marked italic and the three signatures (9, 12 and 16) suggested to also be present in breast cancers—bold.