Table 3.
Change in cardiac repolarization among patients with T2DM and control participants without diabetes during euglycemia and hypoglycemia
| Change from baseline |
Euglycemia vs. hypoglycemia adjusted P value | ||
|---|---|---|---|
| Euglycemia | Hypoglycemia | ||
| QTc (ms) | |||
| Control | Δ 21 ± 4 | Δ 57 ± 5 | 0.08 |
| T2DM | Δ 14 ± 4 | Δ 76 ± 20 | 0.0009 |
| T-wave symmetry | |||
| Control | Δ −0.22 ± 0.04 | Δ −0.20 ± 0.06 | 0.98 |
| T2DM | Δ −0.21 ± 0.06 | Δ −0.52 ± 0.14* | 0.09 |
| Tamp norm | |||
| Control | Δ −0.41 ± 0.06 | Δ −0.32 ± 0.18 | 0.74 |
| T2DM | Δ −0.43 ± 0.04 | Δ −0.57 ± 0.06 | 0.42 |
| TWLD | |||
| Control | Δ −476 ± 64 | Δ −404 ± 243 | 0.90 |
| T2DM | Δ −452 ± 41 | Δ −576 ± 53 | 0.70 |
| PCA ratio | |||
| Control | Δ 0.03 ± 0.02 | Δ 0.01 ± 0.05 | 0.90 |
| T2DM | Δ 0.04 ± 0.02 | Δ 0.16 ± 0.05* | 0.03 |
| TCRT | |||
| Control | Δ −0.01 ± 0.04 | Δ −0.002 ± 0.08 | 0.93 |
| T2DM | Δ −0.05 ± 0.17 | Δ 0.02 ± 0.15 | 0.99 |
Data are mean ± SE. Change in measures of repolarization at T120 compared with baseline. Two-way repeated-measures ANOVA with multiple comparisons between glycemic arms (euglycemia vs. hypoglycemia) and between participant groups. Data are from 9 control participants and 10 patients with T2DM. Tamp norm, normalized T-wave amplitude.
*Significant difference between patients with T2DM and control participants without diabetes within each glycemic arm.