Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Top 100 largest TDT test statistics in the simulated data. The left panel is from a small cohort (with family number N = 150 and SNPs number M = 5000) and the right panel from a large cohort (with N = 5000 and M = 106). The triangle points are the true top 10 significant SNPs. The horizontal dashed lines are the thresholds at 100(1–0.05/M)%-quantile of distribution, where M = 5000, 106 in left and right panels respectively
