Table 1.
Implementation of Previously Published Algorithms for Diastolic Dysfunction in the CARDIA Study (Year 25 Visit), 2010–2011
| Algorithm (Reference No.(s)) | Classification | Criteria |
|---|---|---|
| VALIDD Trial (7, 17) | DD | Age 45–54 years and lateral e′ <10 cm/second; or age 55–65 years and lateral e′ <9 cm/second; or age >65 years and lateral e′ <8 cm/second |
| No DD | Anyone not meeting the criteria for VALIDD DD above | |
| ASE 1 (8) | DD | Lateral e′ <10 cm/second and septal e′ <8 cm/second and LAV ≥34 mL/m2 |
| No DD | Lateral e′ ≥10 cm/second and septal e′ ≥8 cm/second and LAV <34 mL/m2 | |
| Probably no DD | Lateral e′ ≥10 cm/second and septal e′ ≥8 cm/second and LAV ≥34 mL/m2 | |
| Indeterminate | Anyone not meeting any of the 3 categories of ASE 1 criteria above | |
| ASE 2 (8) | DD | Lateral e′ <10 cm/second or septal e′ <8 cm/second and LAV ≥34 mL/m2 |
| No DD | Lateral e′ ≥10 cm/second and septal e′ ≥8 cm/second | |
| Indeterminate | Anyone not meeting either of the 2 categories of ASE 2 criteria above | |
| (Modified) Redfield (9) | DD | E/A ratio <0.75 and E/e′ ratio <10 (mild DD) or 0.75 < E/A ratio < 1.5 and deceleration time >140 ms and E/e′ ratio ≥10 (moderate DD) or E/A ratio >1.5 and deceleration time <140 ms and E/e′ ratio ≥10 (severe DD) |
| No DD | 0.75 < E/A ratio < 1.5 and deceleration time >140 ms and E/e′ ratio <10 | |
| Indeterminate | Anyone not meeting either of the 2 categories of (modified) Redfield criteria above |
Abbreviations: ASE, American Society for Echocardiography; CARDIA, Coronary Artery Risk Development in Young Adults; DD, diastolic dysfunction; LAV, left atrial volume; VALIDD, Valsartan in Diastolic Dysfunction.