Table 4.
Standardized or weighted mean differences (effect sizes) reported by meta-analyses of effects of DBS on specific neuropsychological tests
| Neuropsychological Test | Xie et al. (2016) STN (vs. control) (change between groups) | Martínez-Martínez et al. (2017) STN (but includes 1 GPi study) (change within group) | Elgebaly et al. (2017) STN versus GPi (direct comparison) (change between groups) | Elgebaly et al. (2017) Bilateral and Unilateral (indirect comparison) |
|---|---|---|---|---|
| Mini Mental State Exam | 0.06 | |||
| Mattis Dementia Rating Scale | −0.21* | |||
| Digit Span total | −0.05 | |||
| Digit Span forward | 0.08 | |||
| Digit Span backward | −0.14 | 0.19 | ||
| WAIS-R Digit Symbol | −0.16 | |||
| WAIS-R Arithmetic | 0.02 | |||
| Stroop Word reading | −0.21 | |||
| Stroop color naming | −0.31# | |||
| Stroop Color-Word | −0.20* | −0.21 | −0.16 | |
| Trailmaking Part A | 0.03 | −0.02 | −0.05 | |
| Trailmaking Part B | −0.39 | 0.05 | −0.14 | |
| Trailmaking A-B | −0.04 | |||
| Raven's Matrices | −0.15 | 0.06 | ||
| Wisconsin Card Sorting | 0.06@ | |||
| Verbal Fluency overall | −0.27 | |||
| Verbal Fluency—phonemic | −0.49* | −0.04/−0.05 | ||
| Verbal Fluency—semantic | −0.39* | −0.09/−0.29 | ||
| Boston Naming Test | 0.02 | −0.11 | ||
| Rey Auditory Verbal Learning Test—immediate recall | −2.06* | |||
| Rey Auditory Verbal Learning Test—delayed recall | −1.41* | |||
| Paired associate learning | −0.69 | |||
| Beck Depression Inventory | 0.15/0.36 |
*Significantly greater decline in STN DBS versus control; @different versions of WCST considering categories, errors and perseverations; #favors GPi versus STN DBS.