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. 2016 Aug 23;65(11):3396–3409. doi: 10.2337/db16-0136

Figure 3.

Figure 3

FH deficiency alters gene expression patterns differently in WAT and BAT. A–C, G, and H: Perigonadal WAT. Transcripts related to glucose uptake (A), glycolysis (B), lipogenesis and TG synthesis (C), transcription factors related to lipid energy metabolism (G), and mitochondrial fatty acid oxidation (H) were measured by real-time PCR. Adipose tissues studied were from 5-month-old male control and AFHKO mice (n = 8). D–F, I, and J: BAT evaluated as described for perigonadal WAT. K and L: Western blots of the indicated proteins in WAT and BAT, respectively (n = 4, two representative results shown). *P < 0.05; **P < 0.01; ***P < 0.001. C, control; KO, AFHKO.