Table 2.
List of 45 interaction models by considering the inheritance modes and model structures
| SNP1 × SNP2 Inheritance modea | Model structureb | Model labelc | Model Details | ||
|---|---|---|---|---|---|
| Dom-Dom | Full-int | DD_Full | dSNP1 + | dSNP2 + | dSNP1 × dSNP2 |
| Main1+int | DD_M1_int_o1 | dSNP1 + | dSNP1 × dSNP2 | ||
| DD_M1_int_r1 | rdSNP1 + | rdSNP1 × dSNP2 | |||
| Main2+int | DD_M2_int_o2 | dSNP2 + | dSNP1 × dSNP2 | ||
| DD_M2_int_r2 | rdSNP2 + | dSNP1 × rdSNP2 | |||
| Int-only | DD_int_oo | dSNP1 × dSNP2 | |||
| DD_int_or | dSNP1 × rdSNP2 | ||||
| DD_int_ro | rdSNP1 × dSNP2 | ||||
| DD_int_rr | rdSNP1 × rdSNP2 | ||||
| Dom-Rec | Full-int | DR_Full | dSNP1 + | rSNP2 + | dSNP1 × rSNP2 |
| Main1+int | DR_M1_int_o1 | dSNP1 + | dSNP1 × rSNP2 | ||
| DR_M1_int_r1 | rdSNP1 + | rdSNP1 × rSNP2 | |||
| Main2+int | DR_M2_int_o2 | rSNP2 + | dSNP1 × rSNP2 | ||
| DR_M2_int_r2 | rrSNP2 + | dSNP1 × rrSNP2 | |||
| Int-only | DR_int_oo | dSNP1 × rSNP2 | |||
| DR_int_or | dSNP1 × rrSNP2 | ||||
| DR_int_ro | rdSNP1 × rSNP2 | ||||
| DR_int_rr | rdSNP1 × rrSNP2 | ||||
| Rec-Dom | Full-int | RD_Full | rSNP1 + | dSNP2 + | rSNP1 × dSNP2 |
| Main1+int | RD_M1_int_o1 | rSNP1 + | rSNP1 × dSNP2 | ||
| RD_M1_int_r1 | rrSNP1 + | rrSNP1 × dSNP2 | |||
| Main2+int | RD_M2_int_o2 | dSNP2 + | rSNP1 × dSNP2 | ||
| RD_M2_int_r2 | rdSNP2 + | rSNP1 × rdSNP2 | |||
| Int-only | RD_int_oo | rSNP1 × dSNP2 | |||
| RD_int_or | rSNP1 × rdSNP2 | ||||
| RD_int_ro | rrSNP1 × dSNP2 | ||||
| RD_int_rr | rrSNP1 × rdSNP2 | ||||
| Rec-Rec | Full-int | RR_Full | rSNP1 + | rSNP2 + | rSNP1 × rSNP2 |
| Main1+int | RR_M1_int_o1 | rSNP1 + | rSNP1 × rSNP2 | ||
| RR_M1_int_r1 | rrSNP1 + | rrSNP1 × rSNP2 | |||
| Main2+int | RR_M2_int_o2 | rSNP2 + | rSNP1 × rSNP2 | ||
| RR_M2_int_r2 | rrSNP2 + | rSNP1 × rrSNP2 | |||
| Int-only | RR_int_oo | rSNP1 × rSNP2 | |||
| RR_int_or | rSNP1 × rrSNP2 | ||||
| RR_int_ro | rrSNP1 × rSNP2 | ||||
| RR_int_rr | rrSNP1 × rrSNP2 | ||||
| Add_Add | Full-int | AA_Full | aSNP1 + | aSNP2 + | aSNP1 × aSNP2 |
| Main1+int | AA_M1_int_o1 | aSNP1 + | aSNP1 × aSNP2 | ||
| AA_M1_int_r1 | raSNP1 + | raSNP1 × aSNP2 | |||
| Main2+int | AA_M2_int_o2 | aSNP2 + | aSNP1 × aSNP2 | ||
| AA_M2_int_r2 | raSNP2 + | aSNP1 × raSNP2 | |||
| Int-only | AA_int_oo | aSNP1 × aSNP2 | |||
| AA_int_or | aSNP1 × raSNP2 | ||||
| AA_int_ro | raSNP1 × aSNP2 | ||||
| AA_int_rr | raSNP1 × raSNP2 | ||||
a
Dom: dominant, Rec: recessive, Add: additive.
b
Full-int: full interaction model with two main effects plus an interaction; Main1 + int: main effect of variable 1 plus an interaction; Main2 + int: main effect of variable 2 plus an interaction; and (4) Int-only: an interaction only.
c
_o1, _r1: minor allele (original coding), and reverse coding of SNP1.
_o2, _r2: minor allele (original coding), and reverse coding of SNP2.
_oo, _or, _ro, _rr: based on original-original, original-reverse, reverse-original and reverse-reverse coding for SNP1 and SNP2.