Table 3.
Change in Cardiovascular Disease Classification Using Repeated Measurements of Systolic Blood Pressure, Total Cholesterol, and High-Density Lipoprotein Cholesterol as Predictors in a Study of Cardiovascular Disease Risk Prediction, Emerging Risk Factors Collaboration, 1962–2014
| NRI Measure and Modela | NRI | |||||
|---|---|---|---|---|---|---|
| Event NRI | 95% CI | Nonevent NRI | 95% CI | Overall NRIb | 95% CI | |
| Categorical NRI | ||||||
| Model 1 | 0 | Referent | 0 | Referent | 0 | Referent |
| Model 2 | 0.0154 | 0.0084, 0.0224 | 0.0215 | 0.0197, 0.0234 | 0.0369 | 0.0303, 0.0436 |
| Model 3 | 0.0214 | 0.0148, 0.0279 | −0.0037 | −0.0058, −0.0016 | 0.0177 | 0.0110, 0.0243 |
| Continuous NRI | ||||||
| Model 1 | 0 | Referent | 0 | Referent | 0 | Referent |
| Model 2 | 0.0979 | 0.0686, 0.1272 | 0.3583 | 0.3521, 0.3645 | 0.4562 | 0.4256, 0.4867 |
| Model 3 | 0.2234 | 0.2003, 0.2466 | −0.1410 | −0.1488, 0.1333 | 0.0824 | 0.0583, 0.1065 |
Abbreviations: CI, confidence interval; HDL, high-density lipoprotein; NRI, net reclassification improvement; SBP, systolic blood pressure.
a Model 1: baseline measures of SBP, total cholesterol, and HDL cholesterol. Model 2: cumulative mean values of previous measurements of SBP, total cholesterol, and HDL cholesterol. Model 3: longitudinal mixed-effects model of repeated measurements of SBP, total cholesterol, and HDL cholesterol.
b The overall NRI could range from −2 to +2.