Figure 2.

Predicted probability of ovarian cancer among oral contraceptive pill (OCP) users and nonusers by quartile of weighted genetic risk score in a simulated analysis of gene-environment interaction and ovarian cancer risk. Data were obtained from 15 studies in the Ovarian Cancer Association Consortium (30, 38–55). The relative risk parameters were obtained from a standard logistic regression model adjusting for history of endometriosis, first-degree family history of ovarian cancer, parity, tubal ligation, age, and study site. We assumed that approximately 1.3% of women would be diagnosed with ovarian cancer at some point during their lifetime and that 70% of women would use OCPs at some point in their life. The predicted probabilities were estimated by fixing other covariates at their most frequent value. Bars, 95% confidence intervals.