Fig. 1.

Integrative network analysis of cytokine, metabolome and transcriptome datasets from a study of H1N1 virus infection of mice. (A). Using only control samples. Five communities (C₁…C₅; represented by different colors) were detected using the multilevel community detection algorithm (Supplementary Table S2). (B) Using only H1N1 infected samples. Six communities (C₁…C₆) were detected (Supplementary Table S3). (C) Delta centrality based on the ECM, |ECM_control – ECM_H1N1|, for the cytokines in the integrative networks in (A) and (B). (D) Pathway analysis of genes with delta centrality (|ECM_control – ECM_H1N1|) > 0.1 using MetaCore (https://portal.genego.com/); only top 5 pathways are shown). Note: (rectangle: metabolite, circle: gene, triangle: cytokine)