. 2018 Mar 20;13(3):e0193451. doi: 10.1371/journal.pone.0193451

Table 2. Effect of application of OLE loaded NLC on paw edema in rats.

Treatment	Paw volume (mL)
	0 Day	5 Day	12 Day	21 Day
Group-I: OLE-FREE-NLC-Gel (Normal control)	1.34 ± 0.08	1.30 ± 0.04	1.32 ± 0.05	1.31 ± 0.04
Group-I I: CFA (Toxic control)	1.9 ± 0.04	2.1 5± 0.05^#	2.60 ± 0.08^#	2.72 ± 0.02^#
Group-III: CFA+OLE-NLC -Gel	1.4 ± 0.06	1.68 ± 0.07^*	1.47 ± 0.06^**	1.43 ± 0.07^**
Group-IV: CFA + Marketed Gel (1.16% diclofenac)	1.4 6± 0.05	1.60 ± 0.03^**	1.44 ± 0.02^**	1.38 ± 0.03^**

Values expressed as mean ± standard error of mean.

#p<0.01 as compared to control group

*p<0.05

**p<0.01 as compared to toxic control.

The comparisons were made by ANOVA followed by Dunnett’s test.