Table 3. Persons needed to treat to avoid the same number of cardiovascular events over 5 y using selected SBP thresholds and corresponding CVD risk thresholds.
The BPLTTC (n = 47,872).
| SBP threshold | ||||
|---|---|---|---|---|
| 140 mmHg | 150 mmHg | 160 mmHg | ||
| Persons and proportions treated using an SBP threshold | n | 39,231 (39,231 to 39,344) | 33,891 (33,551 to 34,460) | 27,039 (26,245 to 27,882) |
| percentage | 81.9 (81.9 to 82.2) | 70.8 (70.1 to 72.0) | 56.5 (54.8 to 58.2) | |
| Persons and proportions treated using a CVD risk threshold selected to avoid the same number of cardiovascular events | n | 37,730 (34,343 to 42,073) | 24,225 (23,743 to 25,660) | 17,484 (14,108 to 21,333) |
| percentage | 78.8 (71.7 to 87.9) | 50.6 (49.6 to 53.6) | 36.5 (29.5 to 44.6) | |
| Difference in persons and relative difference in proportions treated using SBP and CVD risk thresholds selected to avoid the same number of cardiovascular events | n | −1,501 (−4,888 to +2,842) | −9,667 (−10,717 to −8,504) | −9,556 (−13,095 to −6,603) |
| percentage | −3.8 (−12.5 to +7.2) | −28.5 (−31.1 to −25.6) | −35.3 (−49.9 to −24.2) | |
Estimates with 10,000 repetitions bias-corrected bootstrap with 95% CIs in parentheses. Negative sign represents smaller proportion or lesser number. Positive sign represents bigger proportion or greater number.
Abbreviations: BPLTTC, Blood Pressure Lowering Treatment Trialists’ Collaboration; CI, confidence interval; CVD, cardiovascular disease; SBP, systolic blood pressure.