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. 2015 Oct 7;45(1):186–205. doi: 10.1093/ije/dyv185

Table 3.

Summary crude odds ratios (ORs) and 95% confidence intervals (95% CIs) for recessive and dominant models of association between CRA and variants identified for meta-analysis

Gene/variant Cases vs controls (number of samples) RECESSIVE MODEL: var/var vs wt/wt & wt/var
DOMINANT MODEL: wt/var & var/var vs wt/wt
N Effect size
Heterogeneity
Power N Effect size
Heterogeneity
Power
OR (95% CI) P -value I 2 (95% CI) P -value OR (95% CI) P -value I 2 (95% CI) P- value
APC /c.5465T>A 2805 vs 4369 (4 * ) 4 0.86 (0.69 −1.07) 0.18 0 (0 −93) 0.44 0.25 4 0.97 (0.88 −1.07) 0.53 0 (0 −67) 0.90 0.09
p.Val1822Asp
BHMT /c.716G>A 3691 vs 12 174 (4 * §) 4 0.97 (0.77 −1.22) 0.80 60 (0 −99) 0.06 0.07 4 0.94 (0.87 −1.02) 0.13 0 (0 −84) 0.84 0.38
p.Arg239Gln
PTGS1 /c.22T>C 2551 vs 4342 (4 * §) 4 0.64 (0.28 −1.47) 0.29 0 (0 −45) 0.94 0.18 4 1.04 (0.90 −1.21) 0.60 0 (0 −95) 0.44 0.09
p.Trp8Arg
PTGS1 /c.382C>A p.Leu237Met 1337 vs 1928 (3§) 2 n/a n/a n/a n/a n/a 3 1.03 (0.74 −1.42) 0.87 0 (0 −91) 0.79 0.06
PTGS2 /c.-765G>C 1507 vs 2042 (4) 3 0.76 (0.46 −1.27) 0.30 4 (0 −98) 0.35 0.21 4 0.86 (0.72 −1.03) 0.10 21 (0 −96) 0.28 0.46
PTGS2 /c. * 427T>C 2643 vs 4616 (6 * §) 6 1.08 (0.90 −1.30) 0.39 54 (0 −94) 0.05 0.31 6 1.06 (0.92 −1.22) 0.44 0 (0 −78) 0.57 0.16
PTGS2 /c.640-275T>G 2492 vs 4423 (5 * §) 5 1.12 (0.85 −1.49) 0.43 25 (0 −90) 0.25 0.2 5 0.96 (0.86 −1.08) 0.50 4 (0 −95) 0.39 0.13
CRP /c. * 1082G>A 2016 vs 3465 (3) 3 1.14 (0.84 −1.55) 0.40 67 (0 −99) 0.05 0.44 3 1.03 (0.82 −1.29) 0.80 65 (0 −99) 0.06 0.08
CYP1A1 /c.1384A>G 1846 vs 1853 (3) 2 n/a n/a n/a n/a n/a 3 1.04 (0.84 −1.28) 0.73 35 (0 −99) 0.22 0.07
p.Ile462Val
CYP1A1 /c. * 1189T>C 3126 vs 5079 (5 * §) 5 0.79 (0.54 −1.15) 0.22 0 (0 −0) 0.99 0.27 5 0.89 (0.99 −1.01) 0.06 0 (0 −89) 0.50 0.57
CYP1A2 /c.-9-154C>A 2689 vs 4373 (4 * ) 4 1.08 (0.89 −1.30) 0.45 0 (0 −80) 0.88 0.14 4 1.01 (0.92 −1.12) 0.79 0 (0 −96) 0.51 0.06
GSTM1 3952 vs 3514 (7) n/a n/a n/a n/a n/a n/a 7 1.03 (0.94 −1.13) 0.50 26 (0 −88) 0.23 0.10
GSTP1 /c.313A>G 3945 vs 5320 (6 * §) 6 1.00 (0.88 −1.15) 0.95 0 (n/a −n/a) 0.99 0.05 6 1.00 (0.91 −1.09) 0.91 0 (0 −80) 0.52 0.06
p.Ile105Val
GSTP1 /c.341C>T 1316 vs 1973 (3§) 3 0.78 (0.29 −2.12) 0.63 0 (0 −96) 0.39 0.09 3 0.85 (0.70 −1.04) 0.12 0 (0 −91) 0.71 0.35
p.Ala114Val
GSTT1 4345 vs 3964 (8) n/a n/a n/a n/a n/a n/a 8 1.06 (0.95 −1.19) 0.31 0 (0 −68) 0.32 0.21
MEH /c.337T>C 7387 vs 8774 (12 * §) 11 0.95 (0.85 −1.05) 0.31 15 (0 −77) 0.30 0.16 12 0.96 (0.90 −1.03) 0.23 0 (0 −58) 0.69 0.25
p.Tyr113His
MEH /c.416A>G 7424 vs 8845 (12 * §) 12 1.10 (0.94 −1.29) 0.25 14 (0 −72) 0.31 0.23 12 1.01 (0.94 −1.08) 0.78 0 (0 −57) 0.54 0.06
p.His139Arg
MTHFR /c.677C>T 11362 vs 23 006 (24 * §) 23 0.98 (0.91 −1.06) 0.62 0 (0 −24) 0.93 0.08 22 0.95 (0.90 −1.00) 0.04 0 (0 −13) 0.95 0.77
p.Ala222Val
MTHFR /c1286A>C 6760 vs 15 498 (10 * ) 10 1.07 (0.97 −1.18) 0.20 0 (0 −88) 0.73 0.28 9 1.03 (0.97 −1.10) 0.37 0 (0 −73) 0.72 0.17
p.Glu429Ala
MTRR /c.66A>G 2911 vs 9342 (3) 3 0.93 (0.84 −1.02) 0.13 0 (0 −97) 0.58 0.31 3 0.92 (0.83 −1.02) 0.12 0 (0 −96) 0.6 0.41
p.Ile22Met
MTR /c.2756A>G 4730 vs 13 710 (7 * §) 7 1.00 (0.83 −1.19) 0.96 0 (0 −76) 0.52 0.05 7 1.03 (0.96 −1.11) 0.43 0 (0 −78) 0.75 0.13
p.Asp919Gly
NAT1 2347 vs 3143 (5) 4 1.10 (0.95 −1.26) 0.20 0 (0 −79) 0.79 0.30 4 1.12 (0.96 −1.32) 0.16 41 (0 −98) 0.18 0.50
NAT2 4092 vs 4731 (9) 8 0.88 (0.76 −1.02) 0.09 0 (0 −57) 0.88 0.42 6 0.97 (0.90 −1.05) 0.48 41 (0 −83) 0.11 0.11
NQO1 /c.559C>T 4097 vs 5967 (6 * §) 6 1.24 (0.98 −1.56) 0.07 0 (0 −78) 0.69 0.59 6 1.10 (1.01 −1.20) 0.03 39 (0 −92) 0.15 0.61
p.Pro187Ser
TP53 /c.215C>G 2135 vs 3738 (3 * ) 3 1.10 (0.88 −1.37) 0.39 0 (0 −97) 0.63 0.15 3 1.16 (1.05 −1.30) 0.005 38 (0 −99) 0.20 0.78
p.Arg72Pro
PPARG /c.34C>G 1730 vs 2953 (3 * ) 3 1.12 (0.71 −1.77) 0.61 0 (0 −99) 0.38 0.07 3 1.09 (0.94 −1.25) 0.25 0 (0 −90) 0.77 0.23
p.Pro12Ala
SLC19A1 /c.80G>A 3614 vs 11 467 (4 * §) 4 1.07 (0.87 −1.31) 0.53 74 (24 −99) 0.009 0.30 4 1.01 (0.93 −1.09) 0.87 41 (0 −98) 0.16 0.06
p.His27Arg
TGFB1 /c.29C>T 2840 vs 4218 (4 * ) 4 1.02 (0.83 −1.25) 0.87 55 (0 −97) 0.08 0.06 4 1.04 (0.94 −1.15) 0.42 0 (0 −72) 0.88 0.12
p.Pro10Leu
TGFB1 /c.-1347T>C 2395 vs 3902 (4 * ) 4 1.06 (0.90 −1.26) 0.46 35 (0 −96) 0.20 0.13 4 1.06 (0.95 −1.18) 0.28 40 (0 −96) 0.17 0.19
TGFB1 /c.74G>C 1011 vs 1329 (3) 3 1.97 (0.72 −5.37) 0.19 0 (0 −94) 0.58 0.20 3 1.09 (0.83 −1.43) 0.55 14 (0 −97) 0.31 0.1
p.Arg25Pro
TYMS /TS tandem repeat 1633 vs 2034 (3) 3 1.00 (0.85 −1.17) 0.98 0 (0 −75) 0.90 0.05 3 0.91 (0.79 −1.06) 0.22 0 (0 −97) 0.42 0.25
VDR /c.1024+283G>A 2403 vs 4356 (5 * §) 5 0.99 (0.87 −1.13) 0.85 0 (0 −80) 0.78 0.05 5 1.01 (0.91 −1.12) 0.85 0 (0 −88) 0.47 0.05
XPD /c.2251A>C 3363 vs 3523 (5§) 5 1.06 (0.96 −1.17) 0.26 37 (0 −92) 0.18 0.14 5 1.03 (0.82 −1.30) 0.78 60 (0 −95) 0.04 0.09
p.Lys751Gln
XRCC1 /c.580C>T 4821 vs 5972 (5 * ) 5 1.27 (0.74 −2.20) 0.39 0 (0 −84) 0.40 0.18 5 1.10 (0.98 −1.23) 0.09 0 (0 −75) 0.66 0.41
p.Arg194Trp
XRCC1 /c.1196A>G 5124 vs 6927 (6 * §) 6 0.88 (0.73 −1.05) 0.16 64 (6 −95) 0.02 0.70 6 0.96 (0.88 −1.04) 0.28 0 (0 −75) 0.68 0.19
p.Arg399Gln
XRCC3 /c.722C>T 3183 vs 4514 (4 * §) 4 0.97 (0.84 −1.11) 0.63 0 (0 −64) 0.92 0.07 4 0.92 (0.83 −1.01) 0.08 0 (0 −72) 0.85 0.43
p.Thr241M
8q24.21/rs6983267 3559 vs 9586 (8) 8 1.31 (1.14 −1.52) 0.0003 55 (0 −90) 0.03 1.00 8 1.30 (1.18 −1.44) 1.9x10 −7 14 (0 −83) 0.32 1.00

Note : The associations which were considered to be “positives” or “less credible positives” are indicated in bold type.

*Includes unpublished data from the APC trial.

§Includes unpublished data from CORGI.