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. 2015 Oct 7;45(1):186–205. doi: 10.1093/ije/dyv185

Table 4.

Comparison of summary crude odd ratios (ORs) and 95% confidence intervals (95% CIs) for CRA and CRC associated with variants identified for CRA meta-analysis; genotypic models

Gene/Variant Colorectal adenomas
Colorectal cancer
Cases vs controls (number of samples) var/wt vs wt/wt
var/var vs wt/wt
Cases vs controls (number of samples) var/wt vs wt/wt
var/var vs wt/wt
OR (95% CI) P -value OR (95% CI) P -value OR (95% CI) P -value OR (95% CI) P -value
APC /c.5465T>A 2805 vs 4369 (4) 0.99 (0.89 −1.09) 0.79 0.86 (0.68 −1.07) 0.18 6282 vs 7038 (6) 0.99 (0.92 −1.07) 0.83 0.84 (0.71 −0.98) 0.03
p.Val1822Asp
BHMT /c.716G>A 3691 vs 12 174 (4) 0.94 (0.87 −1.02) 0.16 0.94 (0.81 −1.07) 0.34 – – – – –
p.Arg239Gln
PTGS1 /c.22T>C 2551 vs 4342 (4) 1.06 (0.91 −1.23) 0.48 0.64 (0.28 −1.48) 0.30 – – – – –
p.Trp8Arg
PTGS1 /c.382C>A 1337 vs 1928 (3) – – 1.03 (0.74 −1.42) 0.87 – – – – –
p.Leu237Met
PTGS2 /c.-765G>C 1507 vs 2042 (4) 0.88 (0.73 −1.05) 0.16 0.74 (0.44 −1.23) 0.24 5459 vs 7272 (11) 1.03 (0.95 −1.13) 0.45 1.21 (0.93 −1.57) 0.15
PTGS2 /c.*427T>C 2643 vs 4616 (6) 1.02 (0.88 −1.19) 0.79 1.14 (0.97 −1.33) 0.11 4745 vs 5756 (7) 1.01 (0.93 −1.09) 0.87 1.03 (0.91 −1.17) 0.65
PTGS2 /c.640-275T>G 2492 vs 4423 (5) 0.95 (0.85 −1.07) 0.41 0.99 (0.74 −1.34) 0.97 – – – – –
CRP /c.*1082G>A 2016 vs 3465 (3) 0.96 (0.85 −1.08) 0.53 1.15 (0.77 −1.71) 0.49 – – – – –
CYP1A1 /c.1384A>G 1846 vs 1853 (3) 1.05 (0.85 −1.30) 0.66 – – 10274 vs 11 978 (13) 1.28 (1.01 −1.63) 0.05 1.47 (1.17 −1.85) 0.001
p.Ile462Val
CYP1A1 /c.*1189T>C 3126 vs 5079 (5) 0.90 (0.79 −1.02) 0.11 0.78 (0.52 −1.16) 0.21 4897 vs 6559 (7) 0.94 (0.86 −1.04) 0.23 0.84 (0.56 −1.27) 0.42
CYP1A2 /c.-9-154C>A 2689 vs 4373 (4) 1.00 (0.90 −1.11) 0.96 1.08 (0.89 −1.31) 0.42 3051 vs 5326 (9) 1.13 (0.95 −1.34) 0.18 1.07 (0.92 −1.26) 0.40
GSTM1 3952 vs 3514 (7) – – 1.03 (0.94 −1.13) 0.50 18845 vs 26 662 (43) – – 1.07 (1.01 −1.13) 0.02
GSTP1 /c.313A>G 3945 vs 5320 (6) 0.99 (0.91 −1.09) 0.89 1.00 (0.87 −1.15) 0.99 9267 vs 12 902 (22) 1.05 (0.99 −1.12) 0.11 0.95 (0.86 −1.05) 0.32
p.Ile105Val
GSTP1 /c.341C>T p.Ala114Val 1316 vs 1973 (3) 0.86 (0.70 −1.05) 0.14 0.77 (0.28 −2.07) 0.60 5183 vs 5457 (6) 1.02 (0.91 −1.13) 0.77 0.87 (0.55 −1.37) 0.55
GSTT1 4345 vs 3964 (8) – – 1.06 (0.95 −1.19) 0.31 13410 vs 20 455 (35) – – 1.18 (1.07 −1.31) 0.002
MEH /c.337T>C 7387 vs 8774 (12) 0.96 (0.89 −1.03) 0.24 0.92 (0.82 −1.03) 0.15 – – – – –
p.Tyr113His
MEH /c.416A>G 7424 vs 8845 (12) 1.00 (0.93 −1.07) 0.97 1.10 (0.93 −1.29) 0.26 – – – – –
p.His139Arg
MTHFR /c.677C>T 11362 vs 23 006 (24) 0.95 (0.90 −1.00) 0.04 0.95 (0.88 −1.03) 0.23 27372 vs 39 867 (52) 1.00 (0.94 −1.06) 0.92 0.87 (0.81 −0.94) <0.0005
p.Ala222Val
MTHFR /c1286A>C 6760 vs 15 498 (10) 1.02 (0.95 −1.09) 0.65 1.08 (0.97 −1.20) 0.16 1 7178 vs 24 792 (34) 1.01 (0.97 −1.06) 0.51 0.94 (0.87 −1.01) 0.09
p.Glu429Ala
MTRR /c.66A>G 2911 vs 9342 (3) 0.94 (0.84 −1.06) 0.31 0.90 (0.79 −1.03) 0.12 6170 vs 8732 (9) 0.98 (0.90 −1.07) 0.66 1.04 (0.94 −1.14) 0.47
p.Ile22Met
MTR /c.2756A>G 4730 vs 13 710 (7) 1.02 (0.95 −1.10) 0.53 1.00 (0.84 −1.20) 0.97 1 1829 vs 15 975 (14) 0.97 (0.92 −1.02) 0.27 1.00 (0.83 −1.20) 0.98
p.Asp919Gly
NAT1 2347 vs 3143 (5) 1.14 (0.98 −1.34) 0.10 1.35 (1.02 −1.78) 0.04 4791 vs 6628 (15) 0.80 (0.68 −0.93) 0.003 0.98 (0.79 −1.22) 0.97
NAT2 4092 vs 4731 (9) 0.99 (0.92 −1.08) 0.84 0.86 (0.74 −1.00) 0.06 1 2908 vs 16 483 (26) 1.01 (0.83 −1.22) 0.94 0.95 (0.76 −1.20) 0.68
NQO1 /c.559C>T 4097 vs 5967 (6) 1.08 (0.95 −1.23) 0.25 1.26 (1.00 −1.59) 0.05 5084 vs 5932 (8) 1.14 (0.96 −1.35) 0.12 1.10 (0.76 −1.59) 0.63
p.Pro187Ser
TP53 /c.215C>G 2135 vs 3738 (3) 1.16 (1.04 −1.30) 0.008 1.17 (0.94 −1.47) 0.17 7414 vs 9872 (27) 1.01 (0.89 −1.14) 0.90 1.04 (0.82 −1.31) 0.77
p.Arg72Pro
PPARG /c.34C>G 1730 vs 2953 (3) 1.08 (0.94 −1.25) 0.29 1.14 (0.73 −1.80) 0.56 1 5091 vs 18 690 (17) 0.98 (0.86 −1.11) 0.72 0.91 (0.73 −1.12) 0.37
p.Pro12Ala
SLC19A1 /c.80G>A 3614 vs 11 467 (4) 0.99 (0.90 −1.08) 0.79 1.08 (0.85 −1.35) 0.53 – – – – –
p.His27Arg
TGFB1 /c.29C>T 2840 vs 4218 (4) 1.06 (0.95 −1.18) 0.29 1.04 (0.89 −1.20) 0.63 – – – – –
p.Pro10Leu
TGFB1 /c.-1347T>C 2395 vs 3902 (4) 1.05 (0.94 −1.17) 0.38 1.07 (0.90 −1.28) 0.45 994 vs 2335 (5) 1.12 (0.91 −1.37) >0.05 1.62 (1.30 −2.02) <0.05
TGFB1 /c.74G>C 1011 vs 1329 (3) 1.04 (0.78 −1.38) 0.80 1.97 (0.72 −5.37) 0.18 – – – – –
p.Arg25Pro
TYMS /TS tandem repeat 1633 vs 2034 (3) 0.90 (0.77 −1.06) 0.20 0.94 (0.77 −1.13) 0.49 3519 vs 5289 (5) 0.86 (0.78 −0.95) 0 0.83 (0.73 −0.94) 0.004
VDR /c.1024+283G>A 2403 vs 4356 (5) 1.01 (0.91 −1.14) 0.80 1.00 (0.86 −1.15) 0.96 5607 vs 6202 (7) 0.77 (0.58 −1.02) 0.07 0.51 (0.28 −0.90) 0.02
XPD /c.2251A>C 3363 vs 3523 (5) 1.06 (0.96 −1.18) 0.26 1.07 (0.82 −1.39) 0.63 – – – – –
p.Lys751Gln
XRCC1 /c.580C>T 4821 vs 5972 (5) 1.09 (0.98 −1.23) 0.12 1.29 (0.74 −2.23) 0.37 6635 vs 8488 (11) 0.96 (0.87 −1.07) 0.5 1.10 (0.82 −1.48) 0.52
p.Arg194Trp
XRCC1 /c.1196A>G 5124 vs 6927 (6) 0.98 (0.90 −1.07) 0.61 0.86 (0.72 −1.03) 0.11 7247 vs 8786 (12) 0.99 (0.92 −1.06) 0.72 0.88 (0.79 −0.97) 0.02
p.Arg399Gln
XRCC3 /c.722C>T 3183 vs 4514 (4) 0.92 (0.83 −1.02) 0.10 0.92 (0.79 −1.07) 0.29 4484 vs 5235 (10) 0.92 (0.84 −1.01) 0.09 0.95 (0.72 −1.24) 0.68
p.Thr241M
8q24.21/rs6983267 3559 vs 9586 (8) 1.20 (1.08 −1.33) 0.0006 1.51 (1.27 −1.79) 2.1x10 −6 4 0604 vs 42 672 (19) 1.22 (1.16 −1.28) <0.0005 1.45 (1.39 −1.51) <0.0005

Note : The associations which were considered to be “positives” or “less credible positives” are indicated in bold type.