Fig 3. IPA interaction network for verteporfin and emetine, and differentially expressed genes from our atypical meningioma gene signature.

Genes and drugs candidates are represented as nodes, and are coloured based on fold-change of expression values, ranging from green (down-regulated in atypical meningioma) to red (up-regulated in atypical meningioma). Nodes in white represent genes that were not included in our atypical meningioma gene signature but serve as a link in the network to the candidate drugs. A line connects two nodes if there is any known relationship between the two; solid lines represent direct interactions while dotted lines represent indirect interactions.