Fig 1. Changes in blood glucose during the two experimental periods as assessed by glucose telemetry.

Solid lines represent dosing during the light periods, and dotted lines represent dosing during the dark periods. Top panel: Low insulin dose period (86 nmol/kg insulin (light blue) and 86 nmol/kg insulin + 1 nmol/kg LAG (light green)). Bottom panel: High insulin dose period (120 nmol/kg insulin (dark blue) and 120 nmol/kg insulin + 1 nmol/kg LAG (dark green)). Shaded background highlights the period where the LAG was added to the insulin treatment. Data are expressed as means ± SEM.