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. 2018 Mar 20;13(3):e0194468. doi: 10.1371/journal.pone.0194468

Fig 8. Glucagon effect on body weight, food intake and FGF21.

Fig 8

A) The change in body weight after twice daily dosing for two weeks with insulin (103 nmol/kg), insulin (103 nmol/kg) + LAG (1 nmol/kg) or 4 x insulin (412 nmol/kg) + LAG (1 nmol/kg). B) Average food intake per animal. C) Plasma FGF21(pg/ml). Data are expressed as means ± SEM; n = 12. The significant effects of the LAG in combination with insulin or 4 x insulin, are indicated by **** (p < 0.0001), ** (p = 0.009), * (p = 0.03), respectively (analyzed using one-way ANOVA followed by Tukey’s multiple comparisons test).