Table 5.

Effect of ARR on overall survival. Results from Cox models (a) unadjusted and (b) adjusted for clinical characteristics.

OS		(a) Unadjusted Model		(b) Adjusted Model
Variable	Years since RT	Hazard Ratio	95% CI	Hazard Ratio	95% CI	p-value
ARR > 1.1 vs. ARR < 1.1	0	4.4	(1.2, 16.8)	3.9	(1.01, 15)
	1	3.0	(1.2, 7.4)	2.7	(1.1, 6.7)
	2	2.4	(1.2, 4.7)	2.2	(1.1, 4.3)
	3	2.1	(1.2, 3.4)	1.9	(1.1, 3.2)
	4	1.8	(1.2, 2.7)	1.6	(1.1, 2.5)
	5	1.6	(1.2, 2.3)	1.5	(1.03, 2.2)
	6	1.5	(1.1, 2.1)	1.4	(0.97, 2.0)
ln(bPSA + 1)+				0.91	(0.74, 1.1)	0.33
Gleason*: GS 7 vs. GS 2–6				1.28	(0.89, 1.8)	0.19
Gleason: GS 8–10 vs. GS 2–6				1.37	(0.81, 2.3)	0.25
T-stage**: T2 vs. T1				1.05	(0.70, 1.6)	0.81
T-stage: T3/T4 vs. T1				0.83	(0.45, 1.6)	0.57
Total Dose+				1.02	(0.98, 1.06)	0.31
Age at RT+				1.05	(1.02, 1.07)	0.001
Whole Pelvis				1.4	(0.93, 2.1)	0.10
White vs. Non-White				0.50	(0.33, 0.78)	0.002

Abbreviations: ARR = Adjusted Ratio of Rise; bPSA = pretreatment PSA; RT = radiation therapy. Model Model stratified by hospital.

⁺Hazard ratios for a 1-unit increase.

^*p-value for overall Gleason Score effect = 0.32.

^**p-value for overall T-stage effect = 0.69