Table 3.
Estimated Mean Differences between the GP-AD and DS-AD Groups: Unadjusted and Adjusted for mBADLS Score and Gender.
| Unadjusted Difference | Adjusted Difference | ||||||
|---|---|---|---|---|---|---|---|
| SIB Domain | Label | Mean Diff. | (95% CI) | p-value | Mean Diff. | (95% CI) | p-value |
| Social Interaction | SIB-SI | −0.07 | (−0.41, 0.26) | 0.667 | −0.07 | (−0.37, 0.24) | 0.667 |
| Memory | SIB-M | 0.16 | (−1.35, 1.68) | 0.831 | 0.24 | (−1.08, 1.56) | 0.717 |
| Orientation | SIB-O | 0.51 | (−0.23, 1.24) | 0.176 | 0.42 | (−0.21, 1.06) | 0.192 |
| Orientation to Name | SIB-ON | 0.04 | (−0.33, 0.41) | 0.816 | 0.05 | (−0.30, 0.40) | 0.787 |
| Attention | SIB-A | 0.02 | (−0.81, 0.85) | 0.956 | 0.01 | (−0.77, 0.79) | 0.983 |
| Praxis | SIB-PR | 1.30 | (−0.04, 2.64) | 0.057 | 1.24 | (−0.04, 2.51) | 0.057 |
| Language | SIB-L | −1.97 | (−5.94, 2.01) | 0.333 | −1.95 | (−5.43, 1.53) | 0.272 |
| Visuospatial | SIB-VS | −0.21 | (−1.18, 0.77) | 0.679 | −0.21 | (−1.03, 0.61) | 0.612 |
| Construction | SIB-C | −0.59 | (−1.17, 0.00) | 0.050 | −0.58 | (−1.17, 0.01) | 0.054 |
| SIB Total Score | SIB-TS | −0.79 | (−8.14, 6.56) | 0.833 | −0.85 | (−6.58, 4.89) | 0.772 |
Abbreviations: GP-AD, individuals from the general population with Alzheimer’s disease; DS-AD, persons with Down syndrome and Alzheimer’s disease; CI, confidence interval; SIB, Severe Impairment Battery; mBADLS, modified Bristol Activities of Daily Living Scale.