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. Author manuscript; available in PMC: 2018 Mar 20.
Published in final edited form as: Cell Rep. 2018 Feb 20;22(8):2133–2145. doi: 10.1016/j.celrep.2018.01.074

Figure 1. Genetic Ablation of MiR-33 Results in Obesity and Whole-Body Insulin Resistance.

Figure 1

(A) Body weight of WT and miR-33−/− mice fed a chow diet (CD) or high-fat diet (HFD) for 20 weeks. (n = 20 for CD and ≥ 30 for HFD.)

(B) Representative images of WT and miR-33−/− mice fed a CD or HFD for 20 weeks.

(C) Fat mass of WT and miR-33−/− mice fed a CD or HFD for 20 weeks (n = 6).

(D) Glucose infusion rate (GIR) during hyperinsulinemic-euglycemic clamp in WT and miR-33−/− mice fed a CD for 20 weeks (n = 9).

(E) Whole-body glucose uptake during the hyperinsulinemic-euglycemic clamp in WT and miR-33−/− mice fed a CD for 20 weeks (n = 9).

(F and G) Muscle (F) and adipose tissue (G) 2-deoxyglucose uptake during hyperinsulinemic-euglycemic clamp in WT and miR-33−/− mice fed a CD for 20 weeks (n = 9).

(H) Endogenous glucose production (EGP) measured in the basal period and during the hyperinsulinemic-euglycemic clamp in WT and miR-33−/− mice fed a CD for 20 weeks (n = 9).

(I) Circulating non-esterified fatty acids in WT and miR-33−/− mice fed a CD for 20 weeks (n = 9). All data represent the mean ± SEM, and an asterisk indicates p < 0.05 comparing miR-33−/− with WT mice on the same diet.