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. 2018 Feb 1;41(4):823–830. doi: 10.2337/dc17-1387

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© 2018 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.

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Quantitation of islet endocrine cell types in subjects with and subjects without CF. Insulin area (A) and glucagon area (B) normalized to total tissue area. Linear regression analysis for the relationship between relative insulin and glucagon areas in non-CF (younger) control subjects (C), non-CF (older) control subjects (D), and CF-no DM (E) and CFRD (F) subjects. In a subset of subjects (n = 10 per group), somatostatin area (G) and pancreatic polypeptide area (H) normalized to total tissue area.