Figure 2.

Subgroup analysis for the time from randomization to first report of insulin use (T2) during the WHI DMT in women without diabetes at randomization. BP, blood pressure; C, comparison; I, intervention; wk, week. *Statistical significance of subgroups is based on a test of the interaction between subgroup and randomization group. For the subgroups of age, BMI, physical activity, blood pressure/hypertension, and metabolic syndrome score, a 1-degree-of-freedom trend test of the interaction was used. †Score ranges from 0 (best) to 3 (worst) and is a sum of these binary components: waist circumference ≥88 cm, high cholesterol requiring pills, or blood pressure >130/85 mmHg (or ever treated for hypertension).