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. 2018 Jan 17;67(4):697–703. doi: 10.2337/db17-0937

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© 2018 by the American Diabetes Association.

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Loss of IBC B_ND cells in subjects with autoantibody-positive (AAb+) prediabetes and recent-onset type 1 diabetes (R/O T1D) and some FDRs. A: Diagram of the adsorbent used to identify and enrich for IBCs. B: Representative gating strategy from a healthy control subject (H/C) to identify anergic (B_ND) IBCs. Gates for IgM and IgD are drawn on the basis of T cells (CD19⁻) and verified by using fluorescence minus one controls. C: B_ND cells (as a percentage of CD27⁻ IBC-positive B cells) in peripheral blood of FDRs (n = 103); subjects with AAb+ prediabetes (n = 18), R/O T1D (n = 21), and long-standing type 1 diabetes (L/S T1D) (n = 21) and H/Cs (n = 49). D: B_ND cells (as percentage of CD27⁻ IBC-positive B cells) in blood of FDRs of various age-groups (years). ***P < 0.001 by Student t test. ns, nonsignificant.