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. 2018 Mar 20;7:e32143. doi: 10.7554/eLife.32143

Table 2. Demographic, clinical and genetic features of the UTUC cohort stratified by UroSEEK results.

N % Ten-gene multiplex positive TERT positive Aneuploidy positive UroSEEK positive
All subjects 56 100% 64% 29% 39% 75%
Gender
 Males 24 43% 71% 33% 54% 83%
 Females 32 57% 59% 25% 28% 69%
CKD stage
 0–2 25 45% 68% 36% 44% 76%
 3A 14 25% 50% 21% 43% 71%
 3B 10 18% 80% 20% 40% 80%
 4 4 7% 25% 50% 0% 50%
 5 3 5% 100% 0% 33% 100%
Tumor grade
 Low 6 11% 67% 50% 17% 67%
 High 50 89% 64% 26% 42% 76%
Tumor stage
 Ta 11 20% 73% 55% 45% 82%
 T1 8 14% 50% 0% 38% 75%
 T2 10 18% 80% 20% 10% 80%
 T3 24 43% 67% 33% 54% 79%
 T4 3 5% 0% 0% 0% 0%
Upper urinary tract tumor site
 Lower ureter 17 30% 76% 18% 35% 76%
 Upper ureter 1 2% 100% 0% 0% 100%
 Ureterovesical junction 2 4% 0% 0% 0% 0%
 Lower ureter and upper ureter 2 4% 100% 50% 50% 100%
 Renal pelvis 21 38% 57% 38% 38% 76%
 Renal pelvis and lower ureter 4 7% 75% 25% 50% 100%
 Renal pelvis and upper ureter 5 9% 40% 40% 60% 60%
 Renal pelvis, lower ureter, upper ureter 4 7% 75% 25% 50% 75%
Synchronous bladder cancer
 Present 21 38% 52% 29% 33% 62%
 Absent 35 63% 71% 29% 43% 83%
UTUC risk factors
 Aristolactam-DNA adducts present 54 96% 65% 30% 39% 74%
 Smoking history 10 18% 70% 30% 60% 70%
 CKD, chronic kidney disease.