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. Author manuscript; available in PMC: 2019 Feb 1.
Published in final edited form as: Cell Stem Cell. 2017 Dec 28;22(2):191–205.e9. doi: 10.1016/j.stem.2017.11.016

Figure 6. METTL14 regulates mRNA stability and translation of MYB and MYC.

Figure 6

(A) The mRNA half-life (t1/2) of MYB or MYC transcripts in MM6 cells with (shM14-#1 or shM14-#2) or without (shNS) METTL14 depletion.

(B) CLIP-qPCR showing decreased association of EIF3A with MYB and MYC transcripts in MM6 cells with (shM14-#1 or shM14-#2) or without (shNS) METTL14 depletion.

(C) Ribosome profiling assays. Fractionations of MM6 cell lysates were shown on top. RNAs in different fractions of ribosome were extracted and subjected to qPCR analysis and shown at the bottom.

Mean±SD values are shown for Figures 6A–C. *, p < 0.05; **, p <0.01; ***, p < 0.001; t-test. See also Figure S6.