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. Author manuscript; available in PMC: 2018 Jul 11.
Published in final edited form as: Oncogene. 2018 Jan 11;37(12):1561–1575. doi: 10.1038/s41388-017-0045-7

Figure 2. Signaling pathways mediated by EGFR/EGFRvIII.

Figure 2

EGFR and EGFRvIII are able to transduce signals via classic RTK pathways including the RAS/RAF/MEK/ERK pathway, the PI3K/AKT pathway, the JAK/STAT pathway and the PKC pathway. The function of mitochondrial EGFR was also reported. Mitochondrial EGFR effector includes COXII. EGFR and EGFRvIII can also localize to the nucleus to activate a group of transcription factors and proteins involved in DNA damage responses, such as DNA-PK, PCNA, histone H4 and STATs. EGFRvIII has some unique signaling effectors. Activation of these signaling pathways and effector molecules together promote the fitness of the tumors.