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. Author manuscript; available in PMC: 2018 Jul 11.
Published in final edited form as: Oncogene. 2018 Jan 11;37(12):1561–1575. doi: 10.1038/s41388-017-0045-7

Figure 3. Hierarchical model for EGFR and EGFRvIII signaling.

Figure 3

Rare cells in human GBM tumors that co-amplify EGFR and EGFRvIII show co-expression, with co-expression of EGFR and EGFRvIII driving malignancy more robustly, as compared to cells expressing EGFR or EGFRvIII alone. Most cells in human GBM tumors that co-amplify EGFR and EGFRvIII express predominantly EGFR or EGFRvIII, and cells expressing EGFRvIII can signal in a paracrine manner to cells expressing EGFR. A possible model incorporating these features is shown. See text for details.