Table 5.

Average differences in neurocognitive test z-scores associated with 20mg/dL lower low-density lipoprotein-cholesterol

	SIS		CERAD Word List Learning		CERAD Word List Delay		CERAD Animal Fluency
	Z-score difference* (95% CI)	p- value†	Z-score difference* (95% CI)	p- value†	Z-score difference* (95% CI)	p- value†	Z-score difference* (95% CI)	p-value†
Crude	−0.01 (−0.02, 0.00)	0.03	−0.03 (0.02, 0.05)	<0.01	−0.03 (−0.04, −0.02)	<0.01	−0.02 (−0.03, −0.01)	<0.01
Model 1	0.00 (−0.01, 0.01)	0.77	−0.01 (0.01, 0.03)	<0.01	−0.02 (−0.03, 0.00)	0.01	−0.01 (−0.02, 0.00)	0.04
Model 2	0.01 (0.00, 0.02)	0.01	−0.01 (0.00, 0.02)	0.19	0.00 (−0.01, 0.01)	0.71	0.00 (−0.01, 0.01)	0.55
Model 3	0.01 (0.00, 0.02)	0.10	0.00 (−0.01, 0.01)	0.58	0.00 (−0.01, 0.01)	0.67	0.00 (−0.01, 0.01)	0.93

^*Z-score differences among participants with versus without LOF variants were calculated using all available assessments

^†p-value testing for the average differences in neurocognitive z-scores associated with 20 mmHg lower LDL-C

Abbreviations: CERAD, Consortium to Establish a Registry for Alzheimer’s Disease; CI, confidence interval; SIS, Six-Item Screener

Model 1 includes adjustment for age

Model 2 includes adjustment for variables in Model 1 plus a propensity score for having neurocognitive impairment

Model 3 includes adjustment for variables in Model 2 plus statin use, history of coronary heart disease, history of stroke/transient ischemic attack, and high-sensitivity C-reactive protein