Table 1.
Top protein changes in spontaneous MI
| Entrez Symbol |
UniProt ID | Target Protein Name | Median Fold Change |
P |
|---|---|---|---|---|
|
| ||||
| TNNI | P19429 | troponin I, cardiac | 66.7 | 5.93E-16 |
| ADSSL1 | Q8N142 | adenylosuccinate synthase like 1 | 15.3 | 1.73E-12 |
| CKB, CKM | P12277, P06732 | creatine kinase M-type: B-type heterodimer | 10 | 1.80E-13 |
| FABP3 | P05413 | fatty acid binding protein 3, muscle and heart | 8.3 | 3.69E-11 |
| CSRP3 | P50461 | cysteine and glycine-rich protein 3 | 6.36 | 2.55E-11 |
| ATP5J | P18859 | ATP synthase, mitochondrial Fo complex, subunit F6 | 5.27 | 5.30E-11 |
| MDH1 | P40925 | malate dehydrogenase, cytoplasmic | 5.2 | 4.20E-12 |
| CKM | P06732 | creatine kinase M-type | 3.99 | 1.18E-11 |
| CHCHD10 | Q8WYQ3 | coiled-coil-helix-coiled-coil-helix domain containing 10 | 3.78 | 4.01E-09 |
| MDH2 | P40926 | malate dehydrogenase 2, NAD (mitochondrial) | 3.19 | 4.59E-09 |
| TPM3 | P06753 | tropomyosin 3 | 2.93 | 7.06E-07 |
| REXO2 | Q9Y3B8 | REX2, RNA exonuclease 2 homolog | 2.34 | 1.01E-08 |
| DUSP3 | P51452 | dual specificity phosphatase 3 | 2.08 | 4.31E-05 |
| HIST2H2BE | Q16778 | histone cluster 2, H2be | 2.03 | 1.66E-04 |
| LANCL1 | O43813 | LanC lantibiotic synthetase component C-like 1 | 2.03 | 1.83E-06 |
| TPI1 | P60174 | triosephosphate isomerase 1 | 2.01 | 3.16E-06 |
| HDHD2 | Q9H0R4 | haloacid dehalogenase-like hydrolase domain 2 | 1.94 | 1.08E-07 |
| MB | P02144 | myoglobin | 1.94 | 3.87E-07 |
| CRIP2 | P52943 | cysteine-rich protein 2 | 1.89 | 1.07E-07 |
| TKT | P29401 | transketolase | 1.78 | 6.40E-07 |
| PEBP1 | P30086 | phosphatidylethanolamine-binding protein 1 | 1.66 | 6.35E-06 |
| RPS6KA1 | Q15418 | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 1.66 | 2.34E-05 |
| FCN1 | O00602 | ficolin (collagen/fibrinogen domain containing) 1 | 1.62 | 3.19E-05 |
| PCDHGB1 | Q9Y5G3 | protocadherin gamma subfamily B, 1 | 1.61 | 2.07E-07 |
| GLRX2 | Q9NS18 | glutaredoxin 2 | 1.55 | 1.47E-08 |
| DECR1 | Q16698 | 2,4-dienoyl CoA reductase 1, mitochondrial | 1.51 | 4.64E-04 |
| LST1 | O00453 | leukocyte specific transcript 1 | 1.45 | 3.87E-07 |
| NAP1L2 | Q9ULW6 | nucleosome assembly protein 1-like 2 | 1.27 | 4.10E-04 |
| SUMF2 | Q8NBJ7 | sulfatase modifying factor 2 | 1.24 | 5.05E-05 |
Shown are proteins increased in SMI cases vs. controls with P <6.17E-04, listed in descending fold change from control (Wilcoxon rank-sum on log transformed RFU values). All proteins were also significant and increased within 1 hour after injury in both PMI derivation and validation cohorts (P < 1.05E-05 and P < 1.33E-04, respectively).