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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: J Immunol. 2018 Feb 12;200(7):2313–2326. doi: 10.4049/jimmunol.1601765

Figure 2.

Figure 2

Cdc42 suppresses aberrant Th17 differentiation and Th17 pathogenicity through repression of glycolysis. (A) ECAR of Cdc42+/+LckCre and Cdc42fl/flLckCre naïve CD4+ T cells cultured for 4 days under Th17 polarizing condition. (B) Real-time RT-PCR analysis of mRNA expression of glycolytic genes in Cdc42+/+LckCre and Cdc42fl/flLckCre naïve CD4+ T cells cultured under Th17 polarizing condition. (C) Percentages of IL-17+, IL17+IFNγ+ and IFN-γ+ cells derived from Cdc42+/+LckCre and Cdc42fl/flLckCre naïve CD4+ T cells cultured under Th17 polarizing condition in the presence or absence of 0.3 mM 2-DG. n ≥ 5. Error bars indicate SD. *p < 0.05, **p < 0.01.