Right ventricular systolic pressure (RVSP, mmHg) at baseline, during and after iv infusion of U46619, and while the anesthetized rabbits were breathing electrically generated NO. (A) Comparison of electrically generated NO (20, 40, 80 ppm) with NO diluted from a 500 ppm NO/N2 tank. NO generation was triggered for 0.5 seconds during every breath.
*P<0.05 for time 62 to 65 min versus 61 min (before production of NO breathing). Mean±SD represents measurements at each NO concentration for 5 rabbits. (B) Comparison of triggering the production and delivery of 80 ppm NO during every breath, every other breath, and every third breath. Mean± SD represents measurements at each setting for 3 rabbits.
eNO: electrically generated NO. †P<0.05 for time 62 to 65 min versus 61 min (before production of NO breathing).
Settings: VT= 6 ml/kg, RR=40–50 bpm, FiO2=0.5.