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TM treatment altered (A) the morphology of the action potential with (B) prolonged action potential duration (APD90) and decreased dV/dtmax of hiPSC-CMs. TM treatment downregulated (C) all major cardiac ion channel currents and positively shifted (D) the V1/2 value of INa steady state activation. Up to 30 cells were used for data average for each group. *P<0.05 vs the untreated group.
