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. 2018 Mar 20;8:4909. doi: 10.1038/s41598-018-23244-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Glomerular histologic and ultrastructural findings from the microalbuminuric diabetic patient. (A) A light microscopy image reveals a glomerulus with vaguely nodular mesangial expansion and prominent capillary loops. The surrounding tubular parenchyma reveals initial mild tubular atrophy (periodic acid-Schiff). (B) A transmission electron micrograph shows peripheral glomerular capillaries with thickened GBM and segmental effacement of the overlying epithelial cells. The mesangial regions are expanded due to increased matrix. (C) Glomerular scanning electron micrograph with the corresponding high magnification insets (D,E and F). (C) A partially visible glomerular tuft appears moderately expanded. A podocyte seemingly hypertrophic with a stretched and flattened cell body and initial effacement of the interdigitating foot processes (D arrow, E and F). Occasional pseudocysts of podocyte cell bodies are seen (D, asterisk).