Table 1.
Coding and 3′ UTR changes between the D83-144 and C0360/94 genomes.
| Nucleotide | Polyprotein | Protein | D83-144 | C0360/94 | Location description |
|---|---|---|---|---|---|
| 932 | 280 | M 75 | A | T | Cleavage site at M-E junction |
| 1304 | 404 | E 124 | S | P | E domain 2 |
| 1328 | 412 | E 132 | H | Y | E domain 2 |
| 1448 | 452 | E 172 | I | V | E domain 1 |
| 2370 | 759 | E 479 | A | V | E transmembrane domain |
| 3866 | 1258 | NS2A 133 | A | T | pTMS5 |
| 4007 | 1305 | NS2A 180 | V | L | pTMS7 |
| 4052 | 1320 | NS2A 195 | A | T | pTMS8 |
| 4235 | 1340 | NS2A 215 | L | P | Carboxy-terminus in ER lumen |
| 5709 | 1872 | NS3 399 | K | R | Helicase: domain 2 |
| 7560 | 2489 | NS4B 247 | K | R | Cleavage site at the NS4B-NS5 junction |
| 8577 | 2828 | NS5 339 | I | T | RNA-dependent RNA polymerase (RdRp): α4 helix of the beta-Nuclear localization site (βNLS) |
| 8730 | 2879 | NS5 389 | R | K | RdRp: between the α6 and α7 helices of α/βNLS |
| 10271 | 3′ UTR | — | g | a | — |
| 10288 | 3′ UTR | — | g | a | — |
| 10391 | 3′ UTR | — | u | g | — |
| 10392 | 3′ UTR | — | u | a | — |