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. 2018 Mar 20;8:4879. doi: 10.1038/s41598-018-23212-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ARRB2 is abundantly expressed in human RCC. (A) Heat map generated from The Cancer Genome Atlas (TCGA) database showing relative expression of ARRB1 and ARRB2 in normal and ccRCC patients. (B) Box and whisker plots for ARRB2 gene expression in ccRCC patient compared to normal. Log2-normalized read count [RNA-seq by expectation-maximization (RSEM)] is shown. (C) Heat map showing ARRB1 and ARRB2 genes expression in normal and papillary carcinoma patients from TCGA. (D) Box and whisker plots for ARRB2 in papillary RCC patient compared to normal. (E) Box and whisker plots represent ARRB2 gene expression for tumor samples stratified according to histologic grade. (F) Kaplan–Meier survival plot represents overall survival of ccRCC patients in TCGA for RCC patients categorized according to ARRB2 gene expression (high vs low in comparison to the median expression). For panels (B,D) and (E) the P values were calculated using a log-rank test. Box plot line (from top to bottom): maximum; Q3, third quartile; median; Q1, first quartile; and minimum. P values were calculated by using two-tailed paired Student’s t test. Data shown are mean ± SEM, **P < 0.001 and ***P < 0.0001.