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. 2018 Mar 20;8:4879. doi: 10.1038/s41598-018-23212-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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βArr2 regulates cell cycle progression. (A) Cell cycle analysis. Control and βArr2^ko (5 × 10⁴) cells were counted using LSRII flow cytometer and analyzed for cell cycle status. Bar-plot representation of the distribution of viable cells compared to total cells. **P < 0.001. (B) Bar-plot representation of the distribution of viable gated cells in G1 (P = 0.6311), S (P = 0.6974) and G2 (P = 0.0253) phase. (C) Representative images of Cyclin A and Cyclin D proteins expression in control and βArr2^ko cells. Actin served as a loading control. (D) Representative images depicting active c-Src. Cell lysates were blotted with anti-c-Src pY416 antibody. Actin served as a loading control. (E) Inhibition of c-Src depletes expression of Cyclin A. Cells were treated with PP2 (10 μM) for 24 hr followed by western blotting to detect the indicated proteins. Total c-Src (t-Src) and GAPDH served as loading controls. (F) Schema depicting cell cycle regulation.