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. 2018 Mar 20;8:4916. doi: 10.1038/s41598-018-23317-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) The real component of AC volume susceptibility, χ′, measured from coated MNPs vs frequency suppressed in PEG-PEI and CM-dextran MNPs at frequencies 100–1000 s⁻¹, a result of increased hydrodynamic volume and reduce mobility. (b) The imaginary component of AC susceptibility, χ″, measured from coated MNPs vs frequency displays a peak which shifted to lower frequencies when MNPs were coated with CM-dextran or PEG-PEI to yield particles having larger measured hydrodynamic diameter (~200 nm) compared to their uncoated precursor MNPs (~80 nm). Other coated MNPs having sizes similar to the citrate-stabilized precursor MNPs had both χ′ and χ″ that remained close to original. MNP concentration was 1 ± 0.05 mg Fe/ml for all measurements.