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. 2018 Mar 20;8:4916. doi: 10.1038/s41598-018-23317-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Concentrations (μg/mg tissue) of Fe recovered from spleens, lungs, and livers of mice injected with MNP suspensions. Iron measurements were obtained using inductively-coupled plasma mass spectrometry (ICP-MS) from processed tissues that were collected 48 hours after intravenous injection. Symbols display individual data obtained from a single mouse and median values within a group are indicated by a horizontal line. (b) Plot showing total recovered Fe (total mass in μg) measured by ICP-MS from tissues as described in (a). (■) represents CM-dextran MNP, (▲) represents PEG-PEI MNP, (▼) represents methoxy-PEG-phosphate + rutin MNP, (♦) represents dextran MNP, (*) represents uncoated MNP.