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. 2018 Mar 20;8:4916. doi: 10.1038/s41598-018-23317-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Scatter plot showing calculated percent of injected dose (ID) of iron recovered from livers, spleens and lungs of mice injected with coated MNPs. N = 4 mice for each group, except PEG-PEI MNPs, for which N = 3. (■) represents CM-dextran MNP, (▲) represents PEG-PEI MNP, (▼) represents methoxy-PEG-phosphate + rutin MNP, (♦) represents dextran MNP and (*) represents uncoated MNPs. Statistical analysis of data was performed using non-parametric Mann-Whitney test demonstrating significant differences in deposition in livers and spleens between CM-dextran MNPs and uncoated precursor (citrate-stabilized) MNPs (p = 0.0286). Comparison of iron concentrations measured in lungs of mice injected with PEG-PEI MNPs with those injected with CM-dextran, or with uncoated MNPs yields p = 0.057.