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. 2018 Mar 20;8:4916. doi: 10.1038/s41598-018-23317-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Representative images of Prussian blue stained lung sections of animals treated with MNPs shows distinct patterns of iron accumulation in lungs depending upon particle coating and dose. (a) Lung tissue section from mouse injected with PEG-PEI MNPs (1 mg Fe) showing Prussian blue positive staining appears to have a dispersed pattern and concentrations of blue coloring (nanoparticle rich regions) correlate with alveolar epithelial cells, indicating nanoparticle accumulation in these cells. (b) Lung of mouse injected with CM-dextran MNPs showing a more intense clustering of particles within the interstitial spaces, a distinctly different manifestation than with PEG-PEI MNP distribution. The lower panel of figures provides a 20× magnified view of the boxed region in upper panels.