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. 2018 Mar 14;9:220. doi: 10.3389/fphar.2018.00220

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Copyright © 2018 Hong, Fristiohady, Nguyen, Milovanovic, Huttary, Krieger, Hong, Geleff, Birner, Jäger, Özmen, Krenn and Krupitza.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of focal adhesion kinase (FAK) and myosin light chain 2 (MLC2) protein expression in LECs by specific siRNAs. LECs were transiently transfected with either non-targeting siRNA (n.t.co), or siRNAs inhibiting the expression of FAK and MLC2. Then, MDA-MB231 spheroids were placed on confluent LEC monolayers and co-incubated for 4 h, after which the areas of CCIDs were analyzed using an Axiovert microscope and Zen Little 2012 software. Three independent experiments with at least five replicates were analyzed. Error bars indicate means ± SEM, asterisks and hash significances (p < 0.05; t-test).